Spontaneous Prediction Error Generation in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Spontaneous Prediction Error Generation in Schizophrenia
Goal-directed human behavior is enabled by hierarchically-organized neural systems that process executive commands associated with higher brain areas in response to sensory and motor signals from lower brain areas. Psychiatric diseases and psychotic conditions are postulated to involve disturbances in these hierarchical network interactions, but the mechanism for how aberrant disease signals ar...
متن کاملImpaired error-likelihood prediction in medial prefrontal cortex in schizophrenia
The cognitive impairment in individuals with schizophrenia includes deficits of working memory in dorsolateral prefrontal cortex and deficits of performance monitoring in medial prefrontal cortex (MPFC). Recent work suggests a more general role for MPFC in predicting the outcome of actions and then evaluating those predictions. Here we investigate, in individuals with schizophrenia, two specifi...
متن کاملExpected value and prediction error abnormalities in depression and schizophrenia.
The dopamine system has been linked to anhedonia in depression and both the positive and negative symptoms of schizophrenia, but it remains unclear how dopamine dysfunction could mechanistically relate to observed symptoms. There is considerable evidence that phasic dopamine signals encode prediction error (differences between expected and actual outcomes), with reinforcement learning theories ...
متن کاملMotivational Context Modulates Prediction Error Response in Schizophrenia.
BACKGROUND Recent findings demonstrate that patients with schizophrenia are worse at learning to predict rewards than losses, suggesting that motivational context modulates learning in this disease. However, these findings derive from studies in patients treated with antipsychotic medications, D2 receptor antagonists that may interfere with the neural systems that underlie motivation and learni...
متن کاملError Observation in Schizophrenia
Title of Dissertation: ERROR OBSERVATION IN SCHIZOPHRENIA Monica Constance Mann-Wrobel, Doctor of Philosophy, 2009 Dissertation directed by: Jack J. Blanchard, Ph.D. Professor, Department of Psychology Despite the pervasive and impairing nature of social difficulties in schizophrenia, the causes of these problems are not fully understood. It has been suggested that problems with cognitive funct...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0037843